On the mechanism of action of vitamin B12: theoretical studies of the 2-methyleneglutarate mutase catalyzed rearrangement

Medicine & Life Sciences

• 2-methyleneglutarate mutase 100%
• 3-methylitaconate 51%
• 2-methyleneglutaric acid 50%
• Vitamin B 12 45%
• Genetic Recombination 40%
• cobamamide 34%
• Theoretical Models 33%
• Cyclization 31%
• Hydrogen 24%

Engineering & Materials Science

• Vitamins 62%
• Deprotonation 41%
• Coenzymes 39%
• Protonation 37%
• Cyclization 36%
• Molecular orbitals 35%
• Substrates 29%
• Activation energy 21%
• Atoms 21%
• Hydrogen 16%

Chemical Compounds

• Vitamin 42%
• Fragmentation 34%
• Energy 19%
• Deprotonation 19%
• Ring Opening Reaction 18%
• Hydrogen Atom 18%
• Ab Initio Calculation 17%
• Cyclization Reaction 15%
• Reaction Activation Energy 14%