Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

Stephen Daley, Kristen M. Coakley, Daniel Hu, Katrina Randall, C Jenne, Andre Limnander, Darienne R. Myers, Noelle Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa Miosge, Geoffrey Sjollema, Ed Bertram, Matthew Field, Yunlin (Lilly) Shao, Dan Andrews, Belinda Whittle, S Whitney Barnes, John R. WalkerJason G Cyster, Christopher Goodnow, Jeroen P. Roose

    Research output: Contribution to journalArticle

    Abstract

    Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoanti
    Original languageEnglish
    Pages (from-to)e01020-e01020
    JournaleLife
    Volume2
    Issue number2
    DOIs
    Publication statusPublished - 2013

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