Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

Stephen Daley; Kristen M. Coakley; Daniel Hu; Katrina Randall; C Jenne; Andre Limnander; Darienne R. Myers; Noelle Polakos; Anselm Enders; Carla Roots; Bhavani Balakishnan; Lisa Miosge; Geoffrey Sjollema; Ed Bertram; Matthew Field; Yunlin (Lilly) Shao; Dan Andrews; Belinda Whittle; S Whitney Barnes; John R. Walker; Jason G Cyster; Christopher Goodnow; Jeroen P. Roose

doi:10.7554/eLife.01020

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

Stephen Daley, Kristen M. Coakley, Daniel Hu, Katrina Randall, C Jenne, Andre Limnander, Darienne R. Myers, Noelle Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa Miosge, Geoffrey Sjollema, Ed Bertram, Matthew Field, Yunlin (Lilly) Shao, Dan Andrews, Belinda Whittle, S Whitney Barnes, John R. WalkerJason G Cyster, Christopher Goodnow, Jeroen P. Roose

Research output: Contribution to journal › Article

Abstract

Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoanti

Original language	English
Pages (from-to)	e01020-e01020
Journal	eLife
Volume	2
Issue number	2
DOIs	https://doi.org/10.7554/eLife.01020
Publication status	Published - 2013

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10.7554/eLife.01020

http://hdl.handle.net/1885/11437

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Daley, S., Coakley, K. M., Hu, D., Randall, K., Jenne, C., Limnander, A., Myers, D. R., Polakos, N., Enders, A., Roots, C., Balakishnan, B., Miosge, L., Sjollema, G., Bertram, E., Field, M., Shao, Y., Andrews, D., Whittle, B., Barnes, S. W., ... Roose, J. P. (2013). Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies. eLife, 2(2), e01020-e01020. https://doi.org/10.7554/eLife.01020

@article{cad490ea030e45769cfaf7e76d40a790,

title = "Rasgrp1 mutation increases na{\"i}ve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies",

abstract = "Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoanti",

author = "Stephen Daley and Coakley, {Kristen M.} and Daniel Hu and Katrina Randall and C Jenne and Andre Limnander and Myers, {Darienne R.} and Noelle Polakos and Anselm Enders and Carla Roots and Bhavani Balakishnan and Lisa Miosge and Geoffrey Sjollema and Ed Bertram and Matthew Field and Shao, {Yunlin (Lilly)} and Dan Andrews and Belinda Whittle and Barnes, {S Whitney} and Walker, {John R.} and Cyster, {Jason G} and Christopher Goodnow and Roose, {Jeroen P.}",

year = "2013",

doi = "10.7554/eLife.01020",

language = "English",

volume = "2",

pages = "e01020--e01020",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications",

number = "2",

}

Daley, S, Coakley, KM, Hu, D, Randall, K, Jenne, C, Limnander, A, Myers, DR, Polakos, N, Enders, A, Roots, C, Balakishnan, B, Miosge, L, Sjollema, G, Bertram, E, Field, M, Shao, Y, Andrews, D, Whittle, B, Barnes, SW, Walker, JR, Cyster, JG, Goodnow, C & Roose, JP 2013, 'Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies', eLife, vol. 2, no. 2, pp. e01020-e01020. https://doi.org/10.7554/eLife.01020

TY - JOUR

T1 - Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

AU - Daley, Stephen

AU - Coakley, Kristen M.

AU - Hu, Daniel

AU - Randall, Katrina

AU - Jenne, C

AU - Limnander, Andre

AU - Myers, Darienne R.

AU - Polakos, Noelle

AU - Enders, Anselm

AU - Roots, Carla

AU - Balakishnan, Bhavani

AU - Miosge, Lisa

AU - Sjollema, Geoffrey

AU - Bertram, Ed

AU - Field, Matthew

AU - Shao, Yunlin (Lilly)

AU - Andrews, Dan

AU - Whittle, Belinda

AU - Barnes, S Whitney

AU - Walker, John R.

AU - Cyster, Jason G

AU - Goodnow, Christopher

AU - Roose, Jeroen P.

PY - 2013

Y1 - 2013

N2 - Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoanti

AB - Missense variants are a major source of human genetic variation. Here we analyze a new mouse missense variant, Rasgrp1Anaef, with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange factor. Rasgrp1Anaef mice exhibit anti-nuclear autoanti

U2 - 10.7554/eLife.01020

DO - 10.7554/eLife.01020

M3 - Article

VL - 2

SP - e01020-e01020

JO - eLife

JF - eLife

SN - 2050-084X

IS - 2

ER -

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

Abstract

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