Systems thinking has often been suggested (and sometimes been applied) to improve the development and implementation of regulation (â€œregulatory governanceâ€). But what are the pros and cons of this approach to regulatory governance? Following the logic of meta-research, a systematic and replicable process of synthesizing research findings across a body of original research, this article presents an evidence synthesis of academic literature on systems thinking for and in regulatory governance. Through a staged approach, an initial body of 757 articles are analyzed. The article presents the main findings from the evidence synthesis, presents the gaps in our knowledge, and suggests a future agenda for research on systems thinking for and in regulatory governance.