Understanding the immunological impact of the human mutation explosion

Dan Andrews, Geoffrey Sjollema, Christopher Goodnow

    Research output: Contribution to journalArticle

    Abstract

    The recent development of human exome sequencing technology has revealed that our immune system is riddled with more genetic defects than anyone imagined. As a legacy of the recent human population explosion, we each inherit hundreds of rare mutations that alter the sequence of proteins. This mutation load is ten times higher than that induced by experimental treatment of mice by ethylnitrosourea; a high fraction of which has substantial effects on immune function. This mutation burden is likely to be a major factor in the incidence of many human immune disorders, but understanding this at the level of individual patients will require new bioinformatics and experimental strategies to assess the impact of individual and combined mutations on immune response pathways.
    Original languageEnglish
    Pages (from-to)99-106
    JournalTrends in Immunology
    Volume34
    Issue number3
    DOIs
    Publication statusPublished - 2013

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