TY - JOUR
T1 - Understanding the immunological impact of the human mutation explosion
AU - Andrews, Dan
AU - Sjollema, Geoffrey
AU - Goodnow, Christopher
PY - 2013
Y1 - 2013
N2 - The recent development of human exome sequencing technology has revealed that our immune system is riddled with more genetic defects than anyone imagined. As a legacy of the recent human population explosion, we each inherit hundreds of rare mutations that alter the sequence of proteins. This mutation load is ten times higher than that induced by experimental treatment of mice by ethylnitrosourea; a high fraction of which has substantial effects on immune function. This mutation burden is likely to be a major factor in the incidence of many human immune disorders, but understanding this at the level of individual patients will require new bioinformatics and experimental strategies to assess the impact of individual and combined mutations on immune response pathways.
AB - The recent development of human exome sequencing technology has revealed that our immune system is riddled with more genetic defects than anyone imagined. As a legacy of the recent human population explosion, we each inherit hundreds of rare mutations that alter the sequence of proteins. This mutation load is ten times higher than that induced by experimental treatment of mice by ethylnitrosourea; a high fraction of which has substantial effects on immune function. This mutation burden is likely to be a major factor in the incidence of many human immune disorders, but understanding this at the level of individual patients will require new bioinformatics and experimental strategies to assess the impact of individual and combined mutations on immune response pathways.
U2 - 10.1016/j.it.2012.12.001
DO - 10.1016/j.it.2012.12.001
M3 - Article
SN - 1471-4906
VL - 34
SP - 99
EP - 106
JO - Trends in Immunology
JF - Trends in Immunology
IS - 3
ER -